Estimates creatinine clearance (not BSA-normalised eGFR) using the Cockcroft-Gault equation (Cockcroft & Gault, 1976). Commonly used for drug dosing.
Usage
egfr_cockcroft_gault(
creatinine,
age,
sex,
weight,
creatinine_units = "mg/dl",
label_sex_male = "male",
label_sex_female = "female"
)Arguments
- creatinine
Numeric vector of serum creatinine.
- age
Numeric vector of age in years.
- sex
Vector of sex labels (see
label_sex_male/label_sex_female).- weight
Numeric vector of body weight in kilograms.
- creatinine_units
Units of
creatinine:"mg/dl"(default) or"umol/l".- label_sex_male, label_sex_female
Values in
sexthat denote male and female records. Defaults to"male"/"female".
Interpretation
This equation returns creatinine clearance in mL/min, which is not
normalised to 1.73 m^2 and is not directly comparable with the other
egfr_*() functions. Creatinine clearance overestimates true GFR because
creatinine is secreted by the renal tubules. The equation was derived in
249 hospitalised adults aged 18-92, all male, using non-standardised
(Jaffe) creatinine; it is therefore not IDMS-traceable and differs
systematically from modern eGFR equations. The 15% downward adjustment for
women (the 0.85 factor) is stated in the original 1976 publication, though
it was asserted rather than derived, as the derivation cohort was male.
References
Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16(1):31-41. doi:10.1159/000180580