Estimated Glomerular Filtration Rate (eGFR) Calculators • egfr

egfr is a vectorised R toolkit for estimating glomerular filtration rate (eGFR) and creatinine clearance from serum creatinine, cystatin C, or both. It implements 20 validated adult, paediatric, and neonatal equations, plus helpers for body surface area, KDIGO CKD staging, and unit conversion.

The package is inspired by the kidney.epi package and was ported from the equation set used by eGFR.app.

These equations are screening tools and are not a substitute for measured GFR or clinical judgement.

Installation

Install the released version from R-universe:

install.packages("egfr", repos = "https://mhovd.r-universe.dev")

Or install the development version from GitHub:

# install.packages("remotes")
remotes::install_github("mhovd/egfr")

Quick start

library(egfr)

# CKD-EPI 2021 creatinine (race-free) — recommended for adults
egfr_ckdepi_cr_2021(creatinine = 1.0, age = 50, sex = "female")
#> 68.6

# Fully vectorised: pass vectors for any argument
egfr_ckdepi_cr_2021(
  creatinine = c(0.8, 1.2, 1.5),
  age        = c(40, 65, 72),
  sex        = c("female", "male", "female")
)

# Units: supply creatinine in umol/L instead of mg/dL
egfr_ckdepi_cr_2021(88.4, 50, "female", creatinine_units = "umol/l")

# Classify the result into a KDIGO stage
ckd_stage(egfr_ckdepi_cr_2021(1.0, 50, "female"))
#> "G2"

Available equations

Adult

Function	Equation	Biomarker
`egfr_ckdepi_cr_2021()`	CKD-EPI 2021 (race-free)	creatinine
`egfr_ckdepi_cys_2021()`	CKD-EPI 2021 (race-free)	cystatin C
`egfr_ckdepi_cr_cys_2021()`	CKD-EPI 2021 (race-free)	both
`egfr_ckdepi_cr_2009()`	CKD-EPI 2009 (with race)	creatinine
`egfr_ckdepi_cys_2012()`	CKD-EPI 2012	cystatin C
`egfr_mdrd()`	MDRD 4-variable (IDMS)	creatinine
`egfr_cockcroft_gault()`	Cockcroft-Gault (CrCl)	creatinine
`egfr_ekfc_cr()`	EKFC 2021	creatinine
`egfr_ekfc_cys()`	EKFC 2023	cystatin C
`egfr_ekfc_cr_cys()`	EKFC 2023	both
`egfr_fas_cr()`	Full Age Spectrum 2016	creatinine
`egfr_lund_malmo()`	Lund-Malmoe Revised 2011	creatinine
`egfr_bis_cr()`	Berlin Initiative Study 2012	creatinine

Paediatric & neonatal

Function	Equation	Biomarker
`egfr_schwartz()`	Schwartz bedside 2009	creatinine
`egfr_ckid_u25_cr()`	CKiD U25 2021	creatinine
`egfr_ckid_u25_cys()`	CKiD U25 2021	cystatin C
`egfr_ckid_u25_cr_cys()`	CKiD U25 2021	both
`egfr_ckid_u25_cr_extended()`	CKiD U25 extended (to 30)	creatinine
`egfr_capa()`	CAPA 2014	cystatin C
`egfr_neonatal()`	Neonatal 2022	creatinine

Helpers

Function	Purpose
`bsa()`	Body surface area (Du Bois, Haycock, Mosteller)
`gfr_bsa_adjust()`	Convert between absolute and BSA-normalised GFR
`ckd_stage()`	KDIGO GFR category (G1-G5)
`convert_creatinine()`	mg/dL <-> umol/L

Conventions

All egfr_*() functions return unrounded values in mL/min/1.73m^2, except egfr_cockcroft_gault(), which returns creatinine clearance in mL/min.
Creatinine defaults to mg/dL; pass creatinine_units = "umol/l" to use SI units. Height defaults to cm.
Sex labels default to "male"/"female" and can be customised via label_sex_male / label_sex_female.

egfr